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Article

Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation.

The Journal of cell biology - 28 Mar 2005

Mansukhani Alka, Ambrosetti Davide, Holmes Greg, Cornivelli Lizbeth, Basilico Claudio

Abstract excerpt

Activating mutations in fibroblast growth factor receptor 2 (FGFR2) cause several craniosynostosis syndromes by affecting the proliferation and differentiation of osteoblasts, which form the calvarial bones. Osteoblasts respond to FGF with increased proliferation and inhibition of differentiation. We analyzed the gene expression profiles of osteoblasts expressing FGFR2 activating mutations (C342Y or S252W) and...

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Source

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Identifiers

PMID: 15781477
DOI: 10.1083/jcb.200409182
PMCID: PMC2171836

Genes

FGFR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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