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Article

Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis

21 Mar 2014

Abstract excerpt

BACKGROUND: Osteogenesis is a highly regulated developmental process and continues during the turnover and repair of mature bone. Runx2, the master regulator of osteoblastogenesis, directs a transcriptional program essential for bone formation through genetic and epigenetic mechanisms. While individual Runx2 gene targets have been identified, further insights into the broad spectrum of Runx2 functions required...

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PMID: 24655370
DOI: 10.1186/gb-2014-15-3-r52

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