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Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2

4 Apr 2019

Abstract excerpt

Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in immature osteoblasts, and is down-regulated in mature osteoblasts. Runx2 enhances the proliferation of osteoblast progenitors by directly regulating Fgfr2 and...

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PMID: 30987410
DOI: 10.3390/ijms20071694

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