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Article

Smad4 is required for the normal organization of the cartilage growth plate.

Developmental biology - 15 Aug 2005

Zhang Jishuai, Tan Xiaohong, Li Wenlong, Wang Youliang, Wang Jian, Cheng Xuan, Yang Xiao

Abstract excerpt

Smad4 is the central intracellular mediator of transforming growth factor-beta (TGF-beta) signals. To study the role of Smad4 in skeletal development, we introduced a conditional mutation of the gene in chondrocytes using Cre--loxP system. We showed that Smad4 was expressed strongly in prehypertr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16023633
DOI: 10.1016/j.ydbio.2005.05.036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-16023633-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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