Article
Low Levels of LRRK2 Gene Expression are Associated with LRRK2 SNPs and Contribute to Parkinson's Disease Progression.
Neuromolecular medicine - 1 Jun 2021
Yılmazer Selma, Candaş Esin, Genç Gençer, Alaylıoğlu Merve, Şengül Büşra, Gündüz Ayşegül, Apaydın Hülya, Kızıltan Güneş, Ertan Sibel, Dursun Erdinç, Gezen-Ak Duygu
Abstract excerpt
Parkinson's disease (PD) is a chronic neurodegenerative disease that has relatively slow progression with motor symptoms. Leucine-rich repeat kinase 2 (LRRK2) gene mutations and polymorphisms are suggested to be associated with PD. In this study, we aimed to investigate the association between single-nucleotide polymorphisms (SNPs) of the LRRK2 gene, namely, rs11176013, rs10878371, rs11835105, and PD. Genotypes...
Read the complete abstract on PubMed