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Article

Lrrk2 and Lewy body disease.

Annals of neurology - 1 Feb 2006

Ross Owen A, Toft Mathias, Whittle Andrew J, Johnson Joseph L, Papapetropoulos Spiridon, Mash Deborah C, Litvan Irene, Gordon Mark F, Wszolek Zbigniew K, Farrer Matthew J, Dickson Dennis W

Abstract excerpt

OBJECTIVE: The Lrrk2 kinase domain G2019S substitution is the most common genetic basis of familial and sporadic parkinsonism. Patients harboring the G2019S substitution usually present with clinical Parkinson's disease. METHODS: Herein, we report that the most common neuropathology of G2019S-associated Parkinson's disease is Lewy body disease. RESULTS: Lrrk2 G2019S was observed in approximately 2% (n = 8) of our...

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PMID: 16437559
DOI: 10.1002/ana.20731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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