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Article

Mitochondrial tRNAAla C5601T mutation may modulate the clinical expression of tRNAMet A4435G mutation in a Han Chinese family with hypertension.

Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2018

Zheng Ping, Li Shiliang, Liu Chun, Zha Zhengbiao, Wei Xiang, Yuan Yuan

Abstract excerpt

Mutations in mitochondrial DNA, especially in mitochondrial tRNA (mt-tRNA) genes, are the important causes for maternally inherited hypertension. In this study, we reported the clinical, genetic, and molecular characterization of a Han Chinese family with hypertension. Most strikingly, this family exhibited a high penetrance and expressivity of hypertension. Sequence analysis of the complete mt-tRNA genes showed...

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Identifiers

PMID: 29211511
DOI: 10.1080/10641963.2017.1411497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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