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The Mitochondrial tRNAAsp T7561C, tRNAHis C12153T, and A12172G Mutations May Be Associated with Essential Hypertension in a Han Chinese Pedigree.

Human heredity - 1 Jan 2022

Fu Haiying, Sun Jinming, Xu Xiaoyan

Abstract excerpt

OBJECTIVES: Mutations in mitochondrial tRNA (mt-tRNA) are the important causes for maternally inherited hypertension; however, the pathophysiology of mt-tRNA mutations in clinical expression of hypertension remains poorly understood. MATERIAL AND METHODS: In this study, we report the molecular features of a Han Chinese pedigree with maternally transmitted essential hypertension. The entire mitochondrial genomes...

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PMID: 35344953
DOI: 10.1159/000524163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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