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Article

The role of mitochondrial genome in essential hypertension in a Chinese Han population.

European journal of human genetics : EJHG - 1 Nov 2009

Zhu Hai-Yan, Wang Shi-Wen, Martin Lisa J, Liu Li, Li Yan-Hua, Chen Rui, Wang Lin, Zhang Min-Lu, Benson D Woodrow

Abstract excerpt

Earlier genetic studies of essential hypertension have focused on nuclear genes or family-based mitochondrial screening in Caucasian and African-American pedigrees. The role of mitochondria in sporadic Chinese hypertensives is unknown. We sequenced mitochondrial genomes in 306 age- and gender-balanced Chinese Han hypertensives and controls. In 153 hypertensives, putative functional changes included 4 changes in...

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Identifiers

PMID: 19401720
DOI: 10.1038/ejhg.2009.63
PMCID: PMC2986694

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