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Article

Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing.

International journal of clinical pharmacology and therapeutics - 1 Oct 2012

Ieiri Ichiro, Fukae Masato, Maeda Kazuya, Ando Yukie, Kimura Miyuki, Hirota Takeshi, Nakamura Takeshi, Iwasaki Kazuhide, Matsuki Shunji, Matsuguma Kyoko, Kanda Eri, Deguchi Mariko, Irie Shin, Sugiyama Yuichi

Abstract excerpt

OBJECTIVES: To test whether the multiple phenotype and genotype relationships established using therapeutic dose, can be reproduced following oral microdosing using substrates of CYP2C9 (warfarin and glibenclamide), CYP2C19 (lansoprazole), CYP2D6 (dextromethorphan), and OATPs (glibenclamide). METHODS: A cocktail of test drugs was administered orally under the microdose in liquid or capsule form, and then a...

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Identifiers

PMID: 22853867
DOI: 10.5414/CP201763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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