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Article

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

20 Jun 2011

Abstract excerpt

We describe a generic approach to assemble correctly two heavy and two light chains, derived from two existing antibodies, to form human bivalent bispecific IgG antibodies without use of artificial linkers. Based on the knobs-into-holes technology that enables heterodimerization of the heavy chains, correct association of the light chains and their cognate heavy chains is achieved by exchange of heavy-chain and...

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Identifiers

PMID: 21690412
DOI: 10.1073/pnas.1019002108

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