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Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodies

15 Apr 2011

Abstract excerpt

The strand-exchange engineered domain (SEED) platform was designed to generate asymmetric and bispecific antibody-like molecules, a capability that expands therapeutic applications of natural antibodies. This new protein engineered platform is based on exchanging structurally related sequences of immunoglobulin within the conserved CH3 domains. Alternating sequences from human IgA and IgG in the SEED CH3 domains...

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PMID: 21498564
DOI: 10.1093/protein/gzq123

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