Article
Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-Cλ interface.
mAbs - 1 Jan 2000
Bagert John D, Oganesyan Vaheh, Chiang Chi-I, Iannotti Mike, Lin Jia, Yang Chunning, Payne Sterling, McMahon Will, Edwards Samuel, Dippel Andrew, Hutchinson Mark, Huang Fengying, Aleti Vineela, Niu Chendi, Qian Chen, Denham Jessica, Ferreira Sofia, Pradhan Pallab, Penney Mark, Wang Chunlei, Liu Wenhai, Walseng Even, Mazor Yariv
Abstract excerpt
Bispecific antibodies represent an increasingly large fraction of biologics in therapeutic development due to their expanded scope in functional capabilities. Asymmetric monovalent bispecific IgGs (bsIgGs) have the additional advantage of maintaining a native antibody-like structure, which can provide favorable pharmacology and pharmacokinetic profiles. The production of correctly assembled asymmetric monovalent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.