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Article

Next generation Fc scaffold for multispecific antibodies

15 Nov 2021

Abstract excerpt

Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for desired assembly. This is a considerable hurdle that hinders the development of many immunoglobulin G (IgG)-like bispecific formats. Our approach focuses on the rational...

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Identifiers

PMID: 34877503
DOI: 10.1016/j.isci.2021.103447

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