Article

A Plug-and-Play Approach for the De Novo Generation of Dually Functionalised Bispecifics

2019-05-03

Abstract excerpt

Diseases are multifactorial, with redundancies and synergies between various pathways. However, most of the antibody-based therapeutics in clinical trials and on the market interact with only one target thus limiting their efficacy. The targeting of multiple epitopes could improve the therapeutic index of treatment and counteract mechanisms of resistance. To this effect, a new class of therapeutics emerged:...

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Literature Corpus work: eb552891-f631-5ce7-a677-d0ce32b435e2
DOI: 10.26434/chemrxiv.8068184.v1

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