Article
Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2011
Subramanian Lakshmi, Sarkar Anindita, Shetty Ashwin S, Muralidharan Bhavana, Padmanabhan Hari, Piper Michael, Monuki Edwin S, Bach Ingolf, Gronostajski Richard M, Richards Linda J, Tole Shubha
Abstract excerpt
The sequential production of neurons and astrocytes from neuroepithelial precursors is a fundamental feature of central nervous system development. We report that LIM-homeodomain (LIM-HD) transcription factor Lhx2 regulates this transition in the developing hippocampus. Disrupting Lhx2 function in the embryonic hippocampus by in utero electroporation and in organotypic slice culture caused the premature...
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