Article
The homeobox gene Gsx2 controls the timing of oligodendroglial fate specification in mouse lateral ganglionic eminence progenitors.
Development (Cambridge, England) - 1 Jun 2013
Chapman Heather, Waclaw Ronald R, Pei Zhenglei, Nakafuku Masato, Campbell Kenneth
Abstract excerpt
The homeobox gene Gsx2 has previously been shown to be required for the specification of distinct neuronal subtypes derived from lateral ganglionic eminence (LGE) progenitors at specific embryonic time points. However, its role in the subsequent generation of oligodendrocytes from these progenitors remains unclear. We have utilized conditional gain-of-function and loss-of-function approaches in order to elucidate...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cell Lineage
- Ganglia
- Gene Expression Regulation, Developmental
- Green Fluorescent Proteins
- Homeodomain Proteins
- Mice
- Microscopy, Fluorescence
- Mutation