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Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem Cells<i>In Vivo</i>

16 Aug 2006

Abstract excerpt

To identify the fates that astroglial cells can attain in the postnatal brain, we generated mice carrying an inducible Cre recombinase (Cre-ER(T2)) controlled by the human GFAP promoter (hGFAP). In mice carrying the GCE (hGFAP-Cre-ER(T2)) transgene, OHT (4-hydroxy-tamoxifen) injections induced Cre recombination in astroglial cells at postnatal day 5 and allowed us to permanently tag these cells with reporter...

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PMID: 16914687
DOI: 10.1523/jneurosci.2532-06.2006

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