Article
NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Jul 2010
Piper Michael, Barry Guy, Hawkins John, Mason Sharon, Lindwall Charlotta, Little Erica, Sarkar Anindita, Smith Aaron G, Moldrich Randal X, Boyle Glen M, Tole Shubha, Gronostajski Richard M, Bailey Timothy L, Richards Linda J
Abstract excerpt
The balance between self-renewal and differentiation of neural progenitor cells is an absolute requirement for the correct formation of the nervous system. Much is known about both the pathways involved in progenitor cell self-renewal, such as Notch signaling, and the expression of genes that initiate progenitor differentiation. However, whether these fundamental processes are mechanistically linked, and...
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