Article
Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate.
Science (New York, N.Y.) - 18 Jan 2008
Mangale Vishakha S, Hirokawa Karla E, Satyaki Prasad R V, Gokulchandran Nandini, Chikbire Satyadeep, Subramanian Lakshmi, Shetty Ashwin S, Martynoga Ben, Paul Jolly, Mai Mark V, Li Yuqing, Flanagan Lisa A, Tole Shubha, Monuki Edwin S
Abstract excerpt
The earliest step in creating the cerebral cortex is the specification of neuroepithelium to a cortical fate. Using mouse genetic mosaics and timed inactivations, we demonstrated that Lhx2 acts as a classic selector gene and essential intrinsic determinant of cortical identity. Lhx2 selector activity is restricted to an early critical period when stem cells comprise the cortical neuroepithelium, where it acts...
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