Article
Expression of Tlx in both stem cells and transit amplifying progenitors regulates stem cell activation and differentiation in the neonatal lateral subependymal zone.
Stem cells (Dayton, Ohio) - 1 Sept 2011
Obernier Kirsten, Simeonova Ina, Fila Tatiana, Mandl Claudia, Hölzl-Wenig Gabriele, Monaghan-Nichols Paula, Ciccolini Francesca
Abstract excerpt
Niche homeostasis in the postnatal subependymal zone of the lateral ventricle (lSEZ) requires coordinated proliferation and differentiation of neural progenitor cells. The mechanisms regulating this balance are scarcely known. Recent observations indicate that the orphan nuclear receptor Tlx is an intrinsic factor essential in maintaining this balance. However, the effect of Tlx on gene expression depends on age...
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