Article
FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2011
Hwang Jae-woong, Rajendrasozhan Saravanan, Yao Hongwei, Chung Sangwoon, Sundar Isaac K, Huyck Heidie L, Pryhuber Gloria S, Kinnula Vuokko L, Rahman Irfan
Abstract excerpt
Forkhead box class O 3a (FOXO3) is a member of the FoxO transcription factor subfamily, which regulates the expression of target genes not only through DNA binding as a transcription factor, but also through protein-protein interaction. Although FoxO3 is a well-known transcription factor involved in diverse biological processes, the role of FoxO3 in cigarette smoke (CS)-induced lung inflammation and injury has...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.