The role of NF-κB p65 and Brd4 in oxidative stress driven inflammation

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is caused by prolonged cigarette smoke (CS) exposure. Increased oxidative stress produced by elevated oxidants, derived from cells and CS, or reduced anti-oxidant response is reported in COPD patients. Chronic inflammation is another key characteristic of COPD which persists long after smoking cessation. This suggests that oxidative stress may affect the course of infla...

Topics

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• DNA Damage
• DNA Repair
• Immune Response and Inflammation
• Microsatellite Repeats
• Mutation
• NF-κB Signaling Pathways
• Oxidative Stress
• Pulmonary Disease, Chronic Obstructive

Identifiers and source

Literature Corpus work

59841ac7-3634-5c21-9831-ea79750d1f05

DOI

10.25560/14702