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The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes.

Toxicological sciences : an official journal of the Society of Toxicology - 1 May 2010

Gebel Stephan, Diehl Svenja, Pype Jan, Friedrichs Bärbel, Weiler Horst, Schüller Jutta, Xu Haiyan, Taguchi Keiko, Yamamoto Masayuki, Müller Thomas

Abstract excerpt

Cigarette smoke (CS) imposes a strong oxidative burden on exposed tissues resulting in a severely disturbed oxidant/antioxidant balance, which in the context of chronic exposure is assumed to be a key contributor to CS-related diseases. Because of its emerging central role in orchestrating the general cellular antioxidant response, the pathway leading to the activation of the transcription factor Nrf2 has...

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PMID: 20133372
DOI: 10.1093/toxsci/kfq039

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