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Article

Critical role of FOXO3a in carcinogenesis.

Molecular cancer - 25 Jul 2018

Liu Ying, Ao Xiang, Ding Wei, Ponnusamy Murugavel, Wu Wei, Hao Xiaodan, Yu Wanpeng, Wang Yifei, Li Peifeng, Wang Jianxun

Abstract excerpt

FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA damage and tumorigenesis. It also responds to several cellular stresses such as UV irradiation and oxidative stress. The function of FOXO3a is regulated by a complex network of processes, including post-transcriptional suppression...

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Topics

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Share to Disease Progression
Share to Forkhead Box Protein O3
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Processing, Post-Translational

Source

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Identifiers

PMID: 30045773
DOI: 10.1186/s12943-018-0856-3
PMCID: PMC6060507

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