Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

Abstract excerpt

Cigarette smoking is the major risk factor for developing chronic obstructive pulmonary disease, the fourth leading cause of deaths in the United States. Despite recent advances, the molecular mechanisms involved in the initiation and progression of this disease remain elusive. We used Affymetrix Gene Chip arrays to determine the temporal alterations in global gene expression during the progression of pulmonary...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Air Quality and Health Impacts
• Share to Chronic Obstructive Pulmonary Disease (COPD) Research
• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis