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Article

RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.

Nature cell biology - 19 Jun 2011

Calvo Fernando, Sanz-Moreno Victoria, Agudo-Ibáñez Lorena, Wallberg Fredrik, Sahai Erik, Marshall Christopher J, Crespo Piero

Abstract excerpt

Individual tumour cells move in three-dimensional environments with either a rounded or an elongated 'mesenchymal' morphology. These two modes of movement are tightly regulated by Rho family GTPases: elongated movement requires activation of Rac1, whereas rounded/amoeboid movement engages specific Cdc42 and Rho signalling pathways. In siRNA screens targeting the genes encoding guanine nucleotide exchange factors...

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PMID: 21685891
DOI: 10.1038/ncb2271

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