Article
Deregulation of Rho GTPases in cancer.
Small GTPases - 2 Jul 2016
Porter Andrew P, Papaioannou Alexandra, Malliri Angeliki
Abstract excerpt
In vitro and in vivo studies and evidence from human tumors have long implicated Rho GTPase signaling in the formation and dissemination of a range of cancers. Recently next generation sequencing has identified direct mutations of Rho GTPases in human cancers. Moreover, the effects of ablating genes encoding Rho GTPases and their regulators in mouse models, or through pharmacological inhibition, strongly suggests...
Topics
- Animals
- DNA Copy Number Variations
- Enzyme Inhibitors
- Gene Expression Regulation, Neoplastic
- Humans
- Mutation
- Neoplasms
- rho GTP-Binding Proteins