Article
Migrastatin analogues target fascin to block tumour metastasis.
Nature - 15 Apr 2010
Chen Lin, Yang Shengyu, Jakoncic Jean, Zhang J Jillian, Huang Xin-Yun
Abstract excerpt
Tumour metastasis is the primary cause of death of cancer patients. Development of new therapeutics preventing tumour metastasis is urgently needed. Migrastatin is a natural product secreted by Streptomyces, and synthesized migrastatin analogues such as macroketone are potent inhibitors of metastatic tumour cell migration, invasion and metastasis. Here we show that these migrastatin analogues target the...
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