Article
Noise reduction in genome-wide perturbation screens using linear mixed-effect models.
Bioinformatics (Oxford, England) - 15 Aug 2011
Yu Danni, Danku John, Baxter Ivan, Kim Sungjin, Vatamaniuk Olena K, Salt David E, Vitek Olga
Abstract excerpt
MOTIVATION: High-throughput perturbation screens measure the phenotypes of thousands of biological samples under various conditions. The phenotypes measured in the screens are subject to substantial biological and technical variation. At the same time, in order to enable high throughput, it is often impossible to include a large number of replicates, and to randomize their order throughout the screens....
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