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Article

A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice.

The American journal of pathology - 1 Jun 2002

Nicholes Katrina, Guillet Susan, Tomlinson Elizabeth, Hillan Kenneth, Wright Barbara, Frantz Gretchen D, Pham Thinh A, Dillard-Telm Lisa, Tsai Siao Ping, Stephan Jean-Philippe, Stinson Jeremy, Stewart Timothy, French Dorothy M

Abstract excerpt

Most mouse models of hepatocellular carcinoma have expressed growth factors and oncogenes under the control of a liver-specific promoter. In contrast, we describe here the formation of liver tumors in transgenic mice overexpressing human fibroblast growth factor 19 (FGF19) in skeletal muscle. FGF19 transgenic mice had elevated hepatic alpha-fetoprotein mRNA as early as 2 months of age, and hepatocellular...

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Identifiers

PMID: 12057932
DOI: 10.1016/S0002-9440(10)61177-7
PMCID: PMC1850847

Genes

FGF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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