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Article

Resident stromal cell‐derived MMP‐9 promotes the growth of colorectal metastases in the liver microenvironment

6 Apr 2007

Abstract excerpt

Colorectal cancer, the second leading cause of cancer deaths in the United States, has a high probability of metastasizing to the liver. Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases that are implicated in cancer metastasis and many aspects of tumor progression. Using a splenic injection experimental metastasis model, mice that are genetically deficient in MMP-9 demonstrated a...

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PMID: 17417772
DOI: 10.1002/ijc.22594

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