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Article

Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression.

AIDS (London, England) - 10 Sept 2011

Madlala Paradise, Gijsbers Rik, Christ Frauke, Hombrouck Anneleen, Werner Lise, Mlisana Koleka, An Ping, Abdool Karim Salim S, Winkler Cheryl A, Debyser Zeger, Ndung'u Thumbi

Abstract excerpt

OBJECTIVE: LEDGF/p75, encoded by the PSIP1 gene, interacts with HIV-1 integrase and targets HIV-1 integration into active genes. We investigated the influence of polymorphisms in PSIP1 on HIV-1 acquisition and disease progression in black South Africans. METHODS: Integrase binding domain of LEDGF/p75 was sequenced in 126 participants. Four haplotype tagging SNPs rs2277191, rs1033056, rs12339417 and rs10283923...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Disease Progression
Share to HIV-1
Share to HIV Infections
Share to Integrases
Share to Polymorphism, Single Nucleotide
Share to Reverse Transcriptase Polymerase Chain Reaction
Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21681054
DOI: 10.1097/QAD.0b013e328349c693
PMCID: PMC3233670

Genes

PSIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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