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Article

Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression.

PloS one - 1 Jan 2012

Messiaen Peter, De Spiegelaere Ward, Alcami Jose, Vervisch Karen, Van Acker Petra, Verhasselt Bruno, Meuwissen Pieter, Calonge Esther, Gonzalez Nuria, Gutierrez-Rodero Felix, Rodriguez-Martín Carmen, Sermijn Erica, Poppe Bruce, Vogelaers Dirk, Verhofstede Chris, Vandekerckhove Linos

Abstract excerpt

BACKGROUND: As Lens epithelium-derived growth factor (LEDGF/p75) is an important co-factor involved in HIV-1 integration, the LEDGF/p75-IN interaction is a promising target for the new class of allosteric HIV integrase inhibitors (LEDGINs). Few data are available on the genetic variability of LEDGF/p75 and the influence on HIV disease in vivo. This study evaluated the relation between LEDGF/p75 genetic variation,...

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Identifiers

PMID: 23226247
DOI: 10.1371/journal.pone.0050204
PMCID: PMC3511443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression.PMID 23226247Read ↗

Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in Brazilian HIV-1+ individuals.Semantic proximity Read ↗

Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression.Semantic proximity Read ↗

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapySemantic proximity Read ↗

Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 IntegraseSemantic proximity Read ↗

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency VirusSemantic proximity Read ↗

Expression Analysis of LEDGF/p75, APOBEC3G, TRIM5alpha, and Tetherin in a Senegalese Cohort of HIV-1-Exposed Seronegative IndividualsSemantic proximity Read ↗

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Semantic proximity Read ↗

Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus ReplicationSemantic proximity Read ↗

Blocking the interaction between HIV-1 integrase and human LEDGF/p75: mutational studies, virtual screening and molecular dynamics simulations.Semantic proximity Read ↗

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug DiscoverySemantic proximity Read ↗

Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75Semantic proximity Read ↗

Pharmacophore‐Based Discovery of Small‐Molecule Inhibitors of Protein–Protein Interactions between HIV‐1 Integrase and Cellular Cofactor LEDGF/p75Semantic proximity Read ↗

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