Article
Genome-Wide Analyses Reveal Gene Influence on HIV Disease Progression and HIV-1C Acquisition in Southern Africa.
AIDS research and human retroviruses - 1 Jun 2017
Xie Wen, Agniel Denis, Shevchenko Andrey, Malov Sergey V, Svitin Anton, Cherkasov Nikolay, Baum Marianna K, Campa Adriana, Gaseitsiwe Simani, Bussmann Hermann, Makhema Joseph, Marlink Richard, Novitsky Vladimir, Lee Tun-Hou, Cai Tianxi, O'Brien Stephen J, Essex M
Abstract excerpt
Sub-Saharan Africans infected with HIV-1C make up the largest AIDS patient population in the world and exhibit large heterogeneity in disease progression before initiating antiretroviral therapy. To identify host variants associated with HIV disease progression, we performed genome-wide association studies on a total of 556 treatment-naive HIV-infected individuals in Botswana. We characterized the pattern of HIV...
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