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Article

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

PLoS pathogens - 1 Mar 2007

Hombrouck Anneleen, De Rijck Jan, Hendrix Jelle, Vandekerckhove Linos, Voet Arnout, De Maeyer Marc, Witvrouw Myriam, Engelborghs Yves, Christ Frauke, Gijsbers Rik, Debyser Zeger

Abstract excerpt

Retroviruses by definition insert their viral genome into the host cell chromosome. Although the key player of retroviral integration is viral integrase, a role for cellular cofactors has been proposed. Lentiviral integrases use the cellular protein LEDGF/p75 to tether the preintegration complex to the chromosome, although the existence of alternative host proteins substituting for the function of LEDGF/p75 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17397262
DOI: 10.1371/journal.ppat.0030047
PMCID: PMC1839165

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Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.PMID 17397262Read ↗

Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1ReplicationSemantic proximity Read ↗

Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactorSemantic proximity Read ↗

An Essential Role for LEDGF/p75 in HIV IntegrationSemantic proximity Read ↗

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency VirusSemantic proximity Read ↗

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapySemantic proximity Read ↗

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV InfectionSemantic proximity Read ↗

Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus ReplicationSemantic proximity Read ↗

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIVSemantic proximity Read ↗

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.Semantic proximity Read ↗

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA IntegrationSemantic proximity Read ↗

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Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 IntegraseSemantic proximity Read ↗

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