Article
Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in Brazilian HIV-1+ individuals.
PloS one - 1 Jan 2014
Passaes Caroline Pereira Bittencourt, Cardoso Cynthia Chester, Caetano Diogo Gama, Teixeira Sylvia Lopes Maia, Guimarães Monick Lindenmeyer, Campos Dayse Pereira, Veloso Valdilea Gonçalves, Babic Dunja Z, Stevenson Mario, Moraes Milton Ozório, Morgado Mariza Gonçalves
Abstract excerpt
The lens epithelium-derived growth factor p75 (LEDGF/p75), coded by the PSIP1 gene, is an important host co-factor that interacts with HIV-1 integrase to target integration of viral cDNA into active genes. The aim of this study was to investigate the association of SNPs in the PSIP1 gene with disease outcome in HIV-1 infected patients. We performed a genetic association study in a cohort of 171 HIV-1 seropositive...
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