Article
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.
American journal of respiratory and critical care medicine - 1 Sept 2011
Gibbons Michael A, MacKinnon Alison C, Ramachandran Prakash, Dhaliwal Kevin, Duffin Rodger, Phythian-Adams Alexander T, van Rooijen Nico, Haslett Christopher, Howie Sarah E, Simpson A John, Hirani Nikhil, Gauldie Jack, Iredale John P, Sethi Tariq, Forbes Stuart J
Abstract excerpt
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a devastating disease. Antiinflammatory therapies, including corticosteroids, are of no benefit. The role of monocytes and macrophages is therefore controversial. OBJECTIVES: To define the role of monocytes and macrophages during lung fibrogenesis and resolution, and explore the phenotype of the cells involved. METHODS: We used multiple in vivo depletional...
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