Article
Circulating monocytes from systemic sclerosis patients with progressive interstitial lung disease preferentially express M2 phenotype markers: in vitro and ex vivo study.
RMD open - 11 Dec 2025
Smith Vanessa, Soldano Stefano, Campitiello Rosanna, Montagna Paola, Cere Andrea, Hysa Elvis, Vojinovic Tamara, Pizzorni Carmen, Paolino Sabrina, Sulli Alberto, Gotelli Emanuele, Cutolo Maurizio
Abstract excerpt
OBJECTIVE: To characterise phenotype and functional profibrotic M2 markers in circulating monocytes and cultured monocyte-derived macrophages (MDMs) from systemic sclerosis (SSc) patients (pts) with progressive interstitial lung disease (ILD) (prog-ILD), non-progressive ILD (no-prog-ILD) and without ILD (no-ILD). METHODS: Fifty-five SSc pts and 20 age-matched healthy controls were evaluated. In 36 SSc pts,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.