Article

Type-1 IFN primed monocytes in pathogenesis of idiopathic pulmonary fibrosis

2020-01-17

Abstract excerpt

<h4>ABSTRACT</h4> Idiopathic pulmonary fibrosis (IPF) is the most severe form of lung fibrosis. It is progressive, and has an extremely poor outcome and limited treatment options. The disease exclusively affects the lungs, and thus less attention has been focused on blood-borne immune cells. which could be a more effective therapeutic target than lung-based cells. Here, we questioned if circulating monocytes, whi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8dc7c8f9-d1a3-5849-95f4-112234196722
DOI: 10.1101/2020.01.16.908749

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Type-1 IFN primed monocytes in pathogenesis of idiopathic pulmonary fibrosisDOI 10.1101/2020.01.16.908749Read

Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype.Semantic proximity Read

Type I IFN-activated lung monocytes and macrophages as initiators and drivers of fibrosis at the alveolar barrier in IPFSemantic proximity Read

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.Semantic proximity Read

The transcriptome of CD14 <sup>+</sup> CD163 <sup>-</sup> HLA-DR <sup>low</sup> monocytes predicts mortality in Idiopathic Pulmonary FibrosisSemantic proximity Read

Monocytes and Macrophages in COVID-19Semantic proximity Read

Early-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1 <sup>+</sup> macrophagesSemantic proximity Read

Reduction in circulating monocytes correlates with persistent post-COVID pulmonary fibrosis in multi-omic comparison of long-haul COVID and IPFSemantic proximity Read

Mass cytometry identifies characteristic immune cell subsets in bronchoalveolar lavage fluid from interstitial lung diseasesSemantic proximity Read

Monocyte Subsets: Phenotypes and Function in Tuberculosis Infection.Semantic proximity Read

Monocyte transcriptome signatures of inflammation and enhanced neutrophil recruitment characterize immunopathology in the blood of tuberculosis patientsSemantic proximity Read

Single-cell multimodal profiling of monocytes reveals diverse phenotypes and alterations linked to cardiovascular disease risksSemantic proximity Read

Monocytes and infection: modulator, messenger and effector.Semantic proximity Read