Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype.

doi:10.3389/fimmu.2021.623430

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Article

Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype.

Frontiers in immunology - 1 Jan 2021

Fraser Emily, Denney Laura, Antanaviciute Agne, Blirando Karl, Vuppusetty Chaitanya, Zheng Yuejuan, Repapi Emmanouela, Iotchkova Valentina, Taylor Stephen, Ashley Neil, St Noble Victoria, Benamore Rachel, Hoyles Rachel, Clelland Colin, Rastrick Joseph M D, Hardman Clare S, Alham Nasullah K, Rigby Rachel E, Simmons Alison, Rehwinkel Jan, Ho Ling-Pei

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is the most severe form of chronic lung fibrosis. Circulating monocytes have been implicated in immune pathology in IPF but their phenotype is unknown. In this work, we determined the immune phenotype of monocytes in IPF using multi-colour flow cytometry, RNA sequencing and corresponding serum factors, and mapped the main findings to amount of lung fibrosis and single cell...

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Identifiers

PMID: 33746960
DOI: 10.3389/fimmu.2021.623430
PMCID: PMC7973086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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