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Article

Farnesylation of Ydj1 is required for in vivo interaction with Hsp90 client proteins.

Molecular biology of the cell - 1 Dec 2008

Flom Gary A, Lemieszek Marta, Fortunato Elizabeth A, Johnson Jill L

Abstract excerpt

Ydj1 of Saccharomyces cerevisiae is an abundant cytosolic Hsp40, or J-type, molecular chaperone. Ydj1 cooperates with Hsp70 of the Ssa family in the translocation of preproteins to the ER and mitochondria and in the maturation of Hsp90 client proteins. The substrate-binding domain of Ydj1 directly interacts with steroid receptors and is required for the activity of diverse Hsp90-dependent client proteins....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18829866
DOI: 10.1091/mbc.e08-04-0435
PMCID: PMC2592663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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