Article
The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2.
Molecular and cellular biology - 1 Jul 2007
Fang Jia, Hogan Gregory J, Liang Gaoyang, Lieb Jason D, Zhang Yi
Abstract excerpt
Histone methylation plays important roles in the regulation of chromatin dynamics and transcription. Steady-state levels of histone lysine methylation are regulated by a balance between enzymes that catalyze either the addition or removal of methyl groups. Using an activity-based biochemical approach, we recently uncovered the JmjC domain as an evolutionarily conserved signature motif for histone demethylases....
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