Article
Cracking the estrogen receptor's posttranslational code in breast tumors.
Endocrine reviews - 1 Oct 2011
Le Romancer Muriel, Poulard Coralie, Cohen Pascale, Sentis Stéphanie, Renoir Jack-Michel, Corbo Laura
Abstract excerpt
Estrogen signaling pathways, because of their central role in regulating the growth and survival of breast tumor cells, have been identified as suitable and efficient targets for cancer therapies. Agents blocking estrogen activity are already widely used clinically, and many new molecules have entered clinical trials, but intrinsic or acquired resistance to treatment limits their efficacy. The basic molecular...
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