A 269-amino-acid segment with a pseudo-leucine zipper and a helix-turn-helix motif codes for the sequence-specific DNA-binding domain of herpes simplex virus type 1 origin-binding protein.

doi:10.1128/JVI.65.6.2829-2838.1991

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Article

A 269-amino-acid segment with a pseudo-leucine zipper and a helix-turn-helix motif codes for the sequence-specific DNA-binding domain of herpes simplex virus type 1 origin-binding protein.

Journal of virology - 1 Jun 1991

Deb S, Deb S P

Abstract excerpt

The UL9 gene of herpes simplex virus (HSV) codes for a DNA-binding protein (OBP) that interacts sequence specifically with the origin of replication. This protein is essential for HSV DNA replication in cultured cells. The UL9 gene was cloned into a plasmid vector downstream of the SP6 RNA polymerase promoter. By using in vitro transcription and translation systems, a full-length OBP was synthesized. This...

Topics

Adenosine Triphosphate
Amino Acid Sequence
Animals
Baculoviridae
Base Sequence
Binding Sites
DNA Replication
DNA, Viral
DNA-Binding Proteins
DNA-Directed RNA Polymerases
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Viral

Leucine Zippers

Molecular Sequence Data

Mutation

Plasmids

Precipitin Tests

Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 1851856
DOI: 10.1128/JVI.65.6.2829-2838.1991
PMCID: PMC240903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1851856-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A 269-amino-acid segment with a pseudo-leucine zipper and a helix-turn-helix motif codes for the sequence-specific DNA-binding domain of herpes simplex virus type 1 origin-binding protein.PMID 1851856Read ↗

Inhibition of herpes simplex virus type 1 DNA replication by mutant forms of the origin-binding protein.Semantic proximity Read ↗

Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo.Semantic proximity Read ↗

A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.Semantic proximity Read ↗

Herpes simplex virus type 1 origin-specific binding protein: oriS-binding properties and effects of cellular proteins.Semantic proximity Read ↗

Two binding sites for the herpes simplex virus type 1 UL9 protein are required for efficient activity of the oriS replication origin.Semantic proximity Read ↗

Characterization of the herpes simplex virus origin binding protein interaction with OriS.Semantic proximity Read ↗

DNA binding activity of the herpes simplex virus type 1 origin binding protein, UL9, can be modulated by sequences in the N terminus: correlation between transdominance and DNA binding.Semantic proximity Read ↗

Herpes simplex virus type 1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2, cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in mice.Semantic proximity Read ↗

Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.Semantic proximity Read ↗

A cosmid-based system for constructing mutants of herpes simplex virus type 1.Semantic proximity Read ↗

The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture.Semantic proximity Read ↗

Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication.Semantic proximity Read ↗

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