Article
Initial characterization of 17 viruses harboring mutant forms of the immediate-early gene of equine herpesvirus 1.
Virus genes - 1 Oct 2005
Buczynski Kimberly A, Kim Seong K, O'Callaghan Dennis J
Abstract excerpt
The sole immediate-early (IE) gene of equine herpesvirus 1 (EHV-1) encodes a major regulatory protein of 1487 amino acids (aa) capable of modulating gene expression from both early and late promoters and also of trans-repressing its own promoter. Using a specially designed recombination system and a library of IE linker-insertion, deletion, point, and nonsense mutant constructs that encode forms of the IE protein...
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