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Article

Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.

PloS one - 1 Jan 2011

Lv Mingyu, Wang Jiawen, Wang Xiaodan, Zuo Tao, Zhu Yingzi, Kong Wei, Yu Xianghui

Abstract excerpt

Tetherin (BST-2/CD317) is an interferon-inducible antiviral protein that restricts the release of enveloped viruses from infected cells. The HIV-1 accessory protein Vpu can efficiently antagonize this restriction. In this study, we analyzed mutations of the transmembrane (TM) domain of Vpu, including deletions and substitutions, to delineate amino acids important for HIV-1 viral particle release and in...

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Identifiers

PMID: 21674066
DOI: 10.1371/journal.pone.0020890
PMCID: PMC3107245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.PMID 21674066Read ↗

Determinants of Tetherin Antagonism in the Transmembrane Domain of the Human Immunodeficiency Virus Type 1 Vpu ProteinSemantic proximity Read ↗

Transmembrane interactions of HIV-1 Vpu and tetherin.Semantic proximity Read ↗

Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestrationSemantic proximity Read ↗

Structural basis of tetherin function.Semantic proximity Read ↗

Modulation of HIV-1-host interaction: role of the Vpu accessory proteinSemantic proximity Read ↗

Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain VariantsSemantic proximity Read ↗

Identification of Alternatively Translated Tetherin Isoforms with Differing Antiviral and Signaling ActivitiesSemantic proximity Read ↗

Suppression of Tetherin-Restricting Activity upon Human Immunodeficiency Virus Type 1 Particle Release Correlates with Localization of Vpu in the <i>trans</i> -Golgi NetworkSemantic proximity Read ↗

Antiviral Inhibition of Enveloped Virus Release by Tetherin/BST-2: Action and CounteractionSemantic proximity Read ↗

Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.Semantic proximity Read ↗

Tetherin/BST-2: Restriction Factor or Immunomodulator?Semantic proximity Read ↗

CD317/Tetherin Is Enriched in the HIV-1 Envelope and Downregulated from the Plasma Membrane upon Virus InfectionSemantic proximity Read ↗

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