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Article

Modulation of HIV-1-host interaction: role of the Vpu accessory protein

1 Dec 2010

Abstract excerpt

Viral protein U (Vpu) is a type 1 membrane-associated accessory protein that is unique to human immunodeficiency virus type 1 (HIV-1) and a subset of related simian immunodeficiency virus (SIV). The Vpu protein encoded by HIV-1 is associated with two primary functions during the viral life cycle. First, it contributes to HIV-1-induced CD4 receptor downregulation by mediating the proteasomal degradation of newly...

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PMID: 21176220
DOI: 10.1186/1742-4690-7-114

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