Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD317/Tetherin Is Enriched in the HIV-1 Envelope and Downregulated from the Plasma Membrane upon Virus Infection

11 Feb 2010

Abstract excerpt

CD317/Bst-2/tetherin is a host factor that restricts the release of human immunodeficiency virus type 1 (HIV-1) by trapping virions at the plasma membrane of certain producer cells. It is antagonized by the HIV-1 accessory protein Vpu. Previous light microscopy studies localized CD317 to the plasma membrane and the endosomal compartment and showed Vpu induced downregulation. In the present study, we performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20147389
DOI: 10.1128/jvi.02421-09

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD317/Tetherin Is Enriched in the HIV-1 Envelope and Downregulated from the Plasma Membrane upon Virus InfectionPMID 20147389Read ↗

Immunoelectron Microscopic Evidence for Tetherin/BST2 as the Physical Bridge between HIV-1 Virions and the Plasma MembraneSemantic proximity Read ↗

Tetherin Can Restrict Cell-Free and Cell-Cell Transmission of HIV from Primary Macrophages to T CellsSemantic proximity Read ↗

Tetherin Restricts Productive HIV-1 Cell-to-Cell TransmissionSemantic proximity Read ↗

Structural basis of tetherin function.Semantic proximity Read ↗

Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestrationSemantic proximity Read ↗

Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.Semantic proximity Read ↗

A Genetic Screen Identifies a Critical Role for the WDR81‐WDR91 Complex in the Trafficking and Degradation of TetherinSemantic proximity Read ↗

Transmembrane interactions of HIV-1 Vpu and tetherin.Semantic proximity Read ↗

Mutation of Glycosylation Sites in BST-2 Leads to Its Accumulation at Intracellular CD63-Positive Vesicles without Affecting Its Antiviral Activity against Multivesicular Body-Targeted HIV-1 and Hepatitis B Virus.Semantic proximity Read ↗

The Nef protein of the macrophage tropic HIV-1 strain AD8 counteracts human Bst-2/tetherinSemantic proximity Read ↗

Rab7A Is Required for Efficient Production of Infectious HIV-1Semantic proximity Read ↗

Vpu Is the Main Determinant for Tetraspanin Downregulation in HIV-1-Infected CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.