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Article

Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.

PLoS pathogens - 1 May 2009

Gupta Ravindra K, Hué Stéphane, Schaller Torsten, Verschoor Ernst, Pillay Deenan, Towers Greg J

Abstract excerpt

The recently identified restriction factor tetherin/BST-2/CD317 is an interferon-inducible trans-membrane protein that restricts HIV-1 particle release in the absence of the HIV-1 countermeasure viral protein U (Vpu). It is known that Tantalus monkey CV1 cells can be rendered non-permissive to HIV-1 release upon stimulation with type 1 interferon, despite the presence of Vpu, suggesting species-specific...

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Identifiers

PMID: 19461879
DOI: 10.1371/journal.ppat.1000443
PMCID: PMC2678251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.PMID 19461879Read ↗

Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain VariantsSemantic proximity Read ↗

Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestrationSemantic proximity Read ↗

Lack of adaptation to human tetherin in HIV-1 Group O and PSemantic proximity Read ↗

Determinants of Tetherin Antagonism in the Transmembrane Domain of the Human Immunodeficiency Virus Type 1 Vpu ProteinSemantic proximity Read ↗

Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In VivoSemantic proximity Read ↗

Molecular Evolution of the Primate Antiviral Restriction Factor TetherinSemantic proximity Read ↗

Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2Semantic proximity Read ↗

A Novel Vpu Adaptive Mutation of HIV-1 Degrades Tetherin in Northern Pig-Tailed Macaques (Macaca leonina) Mainly via the Ubiquitin-Proteasome Pathway and Increases Viral Release.Semantic proximity Read ↗

Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals.Semantic proximity Read ↗

Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity.Semantic proximity Read ↗

Antiviral Activity of the Interferon-Induced Cellular Protein BST-2/TetherinSemantic proximity Read ↗

Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated EndocytosisSemantic proximity Read ↗

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